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阿斯卡里斯隆布里科伊德病毒阳性和COVID-19严重程度之间的负相关性:来自贝宁的一项研究的见解

Tomabu Adjobimey^1,2, Julia Meyer¹, Anneka Hennenfent¹

¹Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Frontiers in immunology

|August 25, 2023

概括

在贝宁,较高的阿斯卡里斯抗体与较温和的COVID-19结果相关. 这表明虫共感染可能会降低严重疾病风险和炎症,为非洲更温和的流行病轨迹提供了洞察力.

科学领域:

传染性疾病传染性疾病
免疫学免疫学免疫学
全球健康全球健康

背景情况:

在全球范围内,COVID-19流行病的严重程度有所不同,低收入和中等收入国家 (LMICs) 观察到较温和的轨迹,特别是在非洲.
假设虫的共感染,例如Ascaris lumbricoides,会影响这些地区的COVID-19疾病严重程度.

研究的目的:

调查阿斯卡里斯特异性抗体水平与贝宁SARS-CoV-2感染的严重程度之间的关联.
探索虫共感染在调节COVID-19结果和炎症反应中的潜在作用.

主要方法:

这项研究涉及贝宁276名SARS-CoV-2感染者,根据COVID-19的严重程度分类 (无症状,轻度,严重).
使用ELISA对阿斯卡里斯和SARS-CoV-2特异性抗体进行了分析.
卢米内克斯测量了测量的细胞因子概况和SARS-CoV-2特异性中和抗体.

主要成果:

与轻度和重度的COVID-19病例相比,无症状个体的阿斯卡里斯抗体水平显著更高 (1.7-2.2倍).
阿斯卡里斯的血清阳性与COVID-19的严重程度相反相关,降低了严重疾病的风险 (OR = 0.277,p = 0.021).
在患有并发症 (糖尿病,高血压) 的患者中观察到较低的阿斯卡里斯抗体,而血清阴性个体显示出较高的促炎标志物.

结论:

升高的阿斯卡里斯抗体水平与无症状的SARS-CoV-2感染有关,并可能降低严重COVID-19的风险.
阿斯卡里斯血清阳性的有益作用可能与减少并发症和较低的全身炎症有关.
研究结果提供了对非洲更温和的COVID-19轨迹的见解,并表明了潜在的治疗影响.

关键词:

阿斯卡里斯 (Ascaris lumbricoides) 是一种虫.在 COVID-19 疫情中,这就是SARS-CoV-2病毒.没有症状的感染.健康的捐赠者健康的捐赠者中和抗体中和抗体.

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