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另一种胆酸途径可以预测儿童早期食物过敏的持续性
So-Yeon Lee1, Yoon Mee Park2, Hyun Ju Yoo3
1Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
概括
婴儿的改变肠胆酸代谢物可能预测持久性食物过敏 (FA). 减少替代通路胆酸和肠道中Clostridia的减少与持续的FA有关,提供了潜在的生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 持续性食物过敏 (FA) 的机制尚不清楚.
- 肠道粘膜是暴露于食物过敏原的主要部位.
- 没有先前的研究研究了与FA持久性相关的肠道代谢物.
研究的目的:
- 研究与FA的发展和持久性相关的早期肠道代谢物和微生物组.
- 为了确定潜在的生物标志物来预测持续的FA.
主要方法:
- 婴儿便样本的非目标代谢分析.
- 对胆汁酸代谢产物和便微生物群的有针对性的代谢分析.
- 3岁婴儿胆汁酸代谢物组成的表征,分为FA缓解和持续的FA组.
主要成果:
- 主要胆汁酸生物合成在FA和健康对照的婴儿之间有显著差异.
- 来自替代途径的肠胆酸代谢物在FA的婴儿中减少.
- 持久性FA是由特定的胆酸代谢产物区分出来的,与卵白特定的IgE负相关.
- 在FA组中观察到肠道克洛斯特里迪亚的丰度下降,与ursodeoxycholic acid相关.
结论:
- 另一种途径的肠胆酸代谢产物显示出在儿童早期持续性FA的预测生物标志物的潜力.
- 需要进一步的研究和复制来验证这些发现.
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