在COVID-19疫苗接种后,甲状腺眼病的风险增加
Ilaria Muller1,2, Dario Consonni3, Erica Crivicich1
1Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
The Journal of clinical endocrinology and metabolism
|August 25, 2023
概括
接种COVID-19疫苗与甲状腺眼病 (TED) 的风险增加有关,特别是在50岁以下的人群中. 建议对接种疫苗的人进行监测,特别是患有自身免疫风险的年轻患者.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- SARS-CoV-2 感染和 COVID-19 疫苗与各种甲状腺疾病有关.
- 甲状腺眼病 (TED) 是一种影响眼睛的自身免疫性疾病,通常与格雷夫斯病有关.
研究的目的:
- 分析COVID-19疫苗接种后发生或重新激活甲状腺眼病 (TED) 的风险.
- 调查COVID-19疫苗接种和TED发作之间的时间关系.
主要方法:
- 一个自我控制的案例系列研究,涉及98名患者,新开发或重新激活了TED.
- 对人日的分析,将暴露期定义为疫苗接种后1-28天,未暴露期定义为该窗口之外.
- 条件波桑回归模型用于计算发病率比率 (IRR) 和95%置信区间 (CI).
主要成果:
- 在接种COVID-19疫苗后观察到TED的风险增加,IRR为3.24 (95%CI为2.01-5.20).
- 在50岁以下的患者中,风险明显更高 (IRR 4.70,95% CI 2.39-9.23).
- 根据性别,吸烟状况或放射性治疗,TED风险没有差异,并且在接种疫苗后随着时间的推移而减少.
结论:
- 接种COVID-19疫苗与甲状腺眼病 (TED) 的风险显著增加有关.
- 在年轻人 (<50岁) 中,风险特别高.
- 潜在的机制涉及尖端蛋白相互作用和免疫反应;建议对有风险的人群进行监测.
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