与大脑网络和抑制执行控制的行为测量相关的双相情感障碍中的化
Tina Chou1, Darin D Dougherty1, Andrew A Nierenberg1
1Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
Acta neuropsychiatrica
|August 25, 2023
概括
在双相情感障碍 (BD) 中,更大的反和执行功能障碍与更强的前对对对控制网络 (FPCN) 和默认模式网络 (DMN) 连接相关. 这表明反可能源于抑制控制失败.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 沉思,一种负面的自我焦点认知,预测双相情感障碍 (BD) 中的抑郁症.
- 患有BD的人表现出抑制性执行控制受损,这表明反可能与执行功能障碍有关.
- 前端对象控制网络 (FPCN) 和默认模式网络 (DMN) 对于执行控制和自我参考思维至关重要.
研究的目的:
- 调查执行功能 (FPCN-DMN连接),行为执行功能和BD患者的反神经测量之间的关系.
- 探索FPCN和DMN在艰苦任务中的功能连接是否与BD中的反和执行功能障碍有关.
主要方法:
- 15名BD患者和15名健康对照人在精神分心任务期间接受了fMRI.
- 使用CONN工具箱计算FPCN和DMN之间的功能连接.
- 皮尔森的r相关性被用来评估连接值,执行功能的行为评分清单 (BRIEF) 和食反应量表 (RRS) 之间的关系.
主要成果:
- 在患有BD的个体中,RRS得分与BRIEF行为调节指数 (BRI) 有正相关.
- 在BD中,在分心期间增加的FPCN-DMN功能连接性与BRI BRI得分正相关.
- 在BD患者中,FPCN-DMN功能连接性也与RRS反性繁殖得分呈正相关.
结论:
- 在双相情感障碍中,增强的反和执行功能障碍与在无关的认知任务中更强的FPCN-DMN连接有关.
- 这种增加的连接性可能代表着持续的努力来抑制反的想法,并重新参与任务.
- 这些发现表明,BD中的反可能是抑制性执行控制受损的表现.
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