生理振荡是生理性的吗?
Lingyun Ivy Xiong1,2, Alan Garfinkel3
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
The Journal of physiology
|August 25, 2023
概括
生理振荡对于避免有毒化学物质水平,抵抗噪音和同步细胞功能至关重要. 用非线性动态重新思考平衡,揭示了生物节奏在健康和疾病中的动态重要性.
科学领域:
- 系统生物学 系统生物学
- 生理学 生理学 生理学
- 生物化学 生物化学
背景情况:
- 生理振荡的功能意义在很大程度上仍未被定义.
- 即使是成熟的振荡过程,如糖溶解,也没有明确的作用.
- 传统的恒温模式无法捕捉到生物系统的动态性质.
研究的目的:
- 使用系统方法论证振荡的关键生理作用.
- 要突出振荡如何防止脱敏和有毒化学物质的积累.
- 提出一种从恒常状态转向健康和疾病的动态观点的范式转变.
主要方法:
- 生理过程的系统级分析.
- 非线性动力学原理的应用.
- 检查胰腺β细胞和胚胎发育中的振荡机制.
主要成果:
- 振荡使系统能够避免脱敏和有毒化学物质水平,并增加抗噪声能力.
- 振荡有助于调和不兼容的条件 (例如,氧化-减氧) 和单位的同步.
- 在胰腺β细胞中,同步的振荡驱动脉动性胰岛素的释放;在发育过程中,它们调节细胞多样性和模式形成.
结论:
- 振荡过程在功能上至关重要,挑战了传统的恒温学说.
- 要了解生物节奏及其在健康和疾病中的作用,需要采用动态,非线性方法.
- 非线性动力学可以识别跨细胞,组织和系统水平的节拍机制.
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