甲状腺功能测试异常 - 隔离的TPOAb+,SCH和低甲状腺血,以及学龄前儿童的神经发育异常
Linlin Zhu1, Yuzhu Teng1, Yufan Guo1
1Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Clinical endocrinology
|August 25, 2023
概括
怀孕20周前母亲甲状腺功能异常与儿童的神经发育问题有关. 这包括同龄人互动,抑制和过度活跃的问题,强调了怀孕期间监测甲状腺健康的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 发育儿科 发育儿科
- 神经科学是一个神经科学.
背景情况:
- 怀孕期间甲状腺功能测试异常是常见的.
- 这些异常与后代的不良神经发育结果有关.
- 早期检测和管理对于胎儿和儿童发育至关重要.
研究的目的:
- 研究怀孕20周前母亲甲状腺功能障碍与3-6岁儿童神经发育之间的关联.
- 评估与母亲甲状腺状况相关的认知,情感和行为发展.
- 为了确定与特定的神经发育挑战相关的特定甲状腺异常.
主要方法:
- 一组2243对母婴对被追溯分析.
- 测量了母体血清甲状腺激素,自由甲状腺素和甲状腺过氧化酶抗体 (TPOAb).
- 通过使用验证的家长问卷 (执行功能-学龄前,优点和困难问卷的行为评分清单) 评估了儿童的神经发育.
- 普森回归模型被用来检查关联,并对混因素进行调整.
主要成果:
- 母亲单独的TPOAb阳性与同龄人问题风险增加有关 (OR=1.90).
- 母亲隔离的亚临床甲状腺功能低下症 (SCH) 与抑制,工作记忆,行为问题,过度活跃和总体困难的风险更高相关.
- 母亲隔离性低甲状腺血与同龄人问题风险增加有关 (OR=2.71).
结论:
- 在怀孕20周之前发现的母体甲状腺功能测试异常可能会对儿童的神经发育产生负面影响.
- 特定的异常,如TPOAb阳性,SCH和低甲状腺血,与不同的神经发育风险有关.
- 这些发现强调了在怀孕早期对母亲甲状腺的监测的重要性.
相关概念视频
Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
Attention-Deficit/Hyperactivity Disorder
131
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
131
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Major Hormones and Their Functions
492
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
492
Information Processing Approach
76
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
76
Environmental Influences on Intelligence
342
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
342


