相关实验视频
Updated: Jul 18, 2025

07:25
Transdermal Measurement of Glomerular Filtration Rate in Mice
Published on: October 21, 2018
22.0K
红细胞病例与功能障碍在感染相关的淋巴结膜炎患者的相关性
Mineaki Kitamura1,2, Laura Biederman1, Dalia Ibrahim3
1From the Division of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus (Kitamura, Biederman, Nadasdy, Brodsky, Satoskar).
Archives of pathology & laboratory medicine
|August 25, 2023
概括
脏活检中的红血细胞 (RBC) 体表明,与感染相关的淋巴结膜炎 (IRGN) 相关的功能障碍更严重. 较高的红细胞成型百分比与较低的估计膜过率 (eGFR) 和增加的细胞新月相相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理学 病理学 病理学
背景情况:
- 感染相关的血球膜炎 (IRGN) 是一种具有可变功能障碍的增殖性免疫复杂血球膜炎.
- IRGN 组织学特征与功能严重程度之间的关联尚未得到充分证实.
研究的目的:
- 调查活检时功能与IRGN. histologic严重程度之间的相关性.
- 为了确定特定的活检发现,预测IRGN患者的功能障碍.
主要方法:
- 对104个经过培养证明的IRGN病例进行了回顾性分析.
- 根据估计的膜过率 (eGFR) 分层的患者<15毫升/分钟/1.73米2.
- 从医疗记录和活检报告中提取的人口统计和组织病理学数据.
主要成果:
- 在51%的IRGN病例中观察到较低的eGFR (<15mL/min/1.73m2).
- 在低EGFR组 (P = .004) 中,具有红细胞 (RBC) 造的管状体的百分比显著更高 (P = .004).
- 与较低的eGFR (OR,1.12;P = .01) 和较高的%细胞新月 (P < .001) 相关的红细胞造的%管道.
结论:
- 脏活检上的红细胞造是IRGN中更严重功能障碍的重要指标.
- 患有IRGN和红细胞造的患者,特别是那些服用抗凝药的患者,由于容易患病,需要仔细监测.
相关概念视频
Renal Corpuscle
2.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.6K
Urine Studies I: Urinalysis
40
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
40
Nephrotic Syndrome I : Introduction
9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9
Acute Kidney Injury IV: Diagnostic Studies and Prevention
34
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
34
Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
Serum Studies: Renal Function Tests
23
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
23

