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利用转录基因剖析来识别分子标记物,预测慢性鼻炎内镜鼻腔手术后的成功康复

Axel E Renteria^1,2, Anastasios Maniakas³, Audrey Pelletier¹

¹Immunopathology Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|August 25, 2023

概括

慢性鼻炎 (CRS) 的成功内镜鼻手术 (ESS) 涉及恢复表皮功能和调节1型炎症. 分子标记可以帮助预测手术结果和量身定制治疗.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

慢性鼻炎 (CRS) 是一种普遍影响生活质量的疾病.
内镜外科手术 (ESS) 是对CRS的常见治疗方法,但手术成功的分子标志物尚未确定.
识别这些标志物可以优化术后管理,改善患者的治疗结果.

研究的目的:

确定与经受ESS治疗的慢性鼻炎患者的成功手术结果相关的新型分子标记物.
了解ESS后成功恢复与失败的分子变化.

主要方法:

对118名具有高复发风险的CRS患者进行前性队列研究.
在ESS后4个月评估了症状和内镜结果.
利用基因表达特征分析分析从手术时间到术后4个月的分子变化.

主要成果:

成功的ESS与1型炎症,细胞循环进展和上皮质屏障/扩散基因的轻度上调相关.
手术失败与非常高的1型炎症和表皮屏障功能和再生基因的下调有关.

结论:

从ESS中成功恢复需要恢复上皮功能和控制1型炎症.
过度的1型炎症是表皮屏障功能障碍和潜在的手术失败的关键指标.

关键词:

这是一种1型炎症.这是一种2型炎症.障碍物功能障碍障碍物功能障碍细胞衰老细胞衰老慢性犀牛鼻炎慢性鼻炎内镜内腔外科手术是指内镜外科手术.表面上皮质的修复.它的表皮质 (epithelium) 是一个表皮质.基因表达的基因表达方式鼻腔多重体是指鼻腔多重体.翻译学翻译学翻译学翻译学伤口愈合伤口愈合

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