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塔克林第一阶段生物转化和相关的肝毒性:一种可能的方法,以避免子甲基的形成

Martin Novak1,2, Marie Vajrychova2, Stefania Koutsilieri3

  • 1Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic.

ACS chemical biology
|August 25, 2023
PubMed
概括

以前与7-OH-tacrine代谢物相关的塔克林肝毒性,可能不遵循金甲基机制. 三维人肝细胞培养揭示了7-OH-tacrine是毒性最小的衍生物,挑战了之前的假设.

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