玻利酸粉末的潜在毒性 视力吸入
Samuel H Smith1, Patrick J Antonelli1
1Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
概括
酸 (BA) 治疗可以提供高度可变的剂量,其中一些超过水平与全身毒性有关. 对BA进行进一步的调查.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 酸 (BA) 粉末是一种常见的用于治疗耳部疾病的局部治疗.
- 炎症的耳道皮肤和粘膜可以很容易地吸收BA.
- 系统性毒性是对每天超过50毫克的BA暴露的担忧.
研究的目的:
- 量化BA的剂量,通过普通的耳腔吸气器传递.
- 提高耳鼻喉学界对耳鼻喉使用可能造成全身毒性的认识.
主要方法:
- 未来的,受控的实验室研究.
- 从四个常见的吸气器中测量BA剂量传递:协奏曲 bellows,House-Sheehy,DeVilbiss和气动粉末吹风机.
- 使用了标准化吸气方法,对每个装置进行十次重复测量.
主要成果:
- 剂量输送因吸入器类型而异.
- 德维尔比斯吸气器提供了最低的平均剂量 (6.1毫克),而调琴 bellows 提供了最高的 (284.1毫克).
- 气动吹风机 (192.8毫克) 和钢琴 (284.1毫克) 的剂量通常超过了与全身毒性相关的50毫克值.
结论:
- 通过吸气器将BA输入眼睛,导致剂量输送高度变化.
- 通常使用的光学BA输送方法可以产生潜在导致全身毒性的剂量.
- 需要提高人们对眼睛BA风险的认识和进一步研究.
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