相关实验视频

Updated: Jul 18, 2025

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

组织系统病理学测试在预测巴雷特食道患者的进展方面优于标准护理变量

Jon M Davison¹, John R Goldblum², Lucas C Duits³

¹University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Clinical and translational gastroenterology

|August 25, 2023

概括

一个新的组织系统病理学 (TSP-9) 测试为巴雷特食道 (BE) 患者提供了改进的风险分层,比目前的方法更有效地识别到高度发育不良/食道腺癌的进展.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

巴雷特食道 (BE) 需要客观的风险分层来进行有效的管理.
目前的临床病理学变量对BE进展的预测性能有限.

研究的目的:

评估组织系统病理学 (TSP-9) 测试 (TissueCypher) 与多中心BE队列中的标准临床病理学变量之间的预测性能.
评估TSP-9测试对不同患者子组风险分层的能力.

主要方法:

分析了5项研究中699名BE患者的数据.
将TSP-9风险类与临床病理学变量 (年龄,性别,细分长度等) 的比较 ) 的情况.
评估TSP-9在预测进展到高度发育不良/食道腺癌 (HGD/EAC) 的表现.

主要成果:

与专家证实的低度发育不良 (LGD) (28.3%) 相比,TSP-9测试在检测进展方面表现出更高的灵敏度 (62.3%).
TSP-9确定了57%的进展者患有非扩张性BE (NDBE),高风险的NDBE患者的进展与LGD患者相似.
通过TSP-9在临床低风险和高风险BE患者群体中实现了显著的风险分层 (P < 0.0001).

结论:

在TSP-9测试中,可以独立预测BE患者的HGD/EAC进展风险.
通过TSP-9测试的客观风险分层可以指导管理决策并改善患者的治疗结果.

更多相关视频

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

相关概念视频

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Barrett Esophagus-II: Clinical Manifestations and Management

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...