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开发和验证帕洛斯米亚嗅觉功能障碍结果评级 (DisODOR) 的发展和验证
Patrick Ioerger1,2, Dorina Kallogjeri1,3, Lauren Roland3
1Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
概括
一个新的生活质量尺度,帕洛斯米亚嗅觉功能障碍结果评分 (DisODOR),有效地测量了患者的嗅觉扭曲. 这种经过验证的工具有助于评估患有帕洛斯米亚的个体的治疗影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生活质量研究 研究 生命质量研究
- 嗅觉功能障碍 嗅觉功能障碍
背景情况:
- 缺血症,包括缺血症,显著影响患者的生活质量.
- 现有的措施可能无法充分捕捉与气味扭曲相关的特定功能障碍.
研究的目的:
- 开发和验证一种新的生活质量 (QoL) 结果测量方法,用于患有松症,特别是松症的患者.
- 创建一个可靠和敏感的仪器来评估气味扭曲对日常工作的影响.
主要方法:
- 一个由59项试点调查被开发出来,来自帕罗斯米亚患者和耳鼻喉科医生的投入.
- 项目减少导致了29项的帕洛斯米亚嗅觉功能障碍结果评分 (DisODOR) 尺度.
- 验证包括评估可靠性,有效性 (面部,内容,收性,歧视性),以及对案例和控制变化的敏感性.
主要成果:
- 迪索多尺度在帕洛斯米亚病例 (n=134) 和对照病例 (n=20) 之间显示出良好的区分有效性.
- 观察到高的测试重复测试可靠性 (r=0.942) 和内部一致性 (克朗巴赫的α=0.971).
- 该尺度与SNOT-22分数有适度的相关性,与严重程度类别有很好的关联,临床重要差异最小 (MCID) 为15.
结论:
- 迪索多 (DisODOR) 是一种有效且可靠的QOL仪器,用于帕洛斯米亚.
- 它准确地测量了帕洛斯米亚患者的功能影响和QoL损伤.
- 这种尺度对变化的敏感性使其适合用于临床试验,用于研究帕洛斯米亚治疗方法.
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