动力系统损伤的病理机械网络在肌缩侧面硬化症中
Bedaballi Dey1,2, Arvind Kumar1,2, Anant Bahadur Patel1,2
1CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad 500007, Telangana, India.
Current neuropharmacology
|August 25, 2023
概括
肌缩侧面硬化症 (ALS) 是一种进展性运动神经元疾病,缺乏诊断生物标志物和有效的治疗方法. 研究突出了影响表观遗传学和表观转录学的基因环境相互作用,为精准医学提供了新的途径.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 环境健康 环境健康
背景情况:
- 肌缩侧面硬化 (ALS) 是一种致命的运动神经退行性疾病,具有显著的异质性.
- 目前治疗ALS的疗效有限,缺乏可靠的诊断或预后生物标志物.
- ALS的发病过程涉及遗传学,环境和内源因素之间的复杂相互作用.
研究的目的:
- 审查ALS复杂的病理机制,重点关注细胞内稳态,细胞网络和多系统方面.
- 突出表观遗传学和表观转录学变化的作用在ALS病理学中,由基因环境相互作用驱动.
- 根据患者分层,为ALS提出精准医学策略.
主要方法:
- 关于ALS研究近期进展的综合文献综述.
- 对研究基因与环境相互作用及其对ALS病变发生的影响的研究进行分析.
- 在ALS中讨论细胞内和细胞网络失调.
主要成果:
- 艾滋病的发病因子受到年龄相关的基因与环境相互作用的影响.
- 表观遗传和表观转录变化是重要的,但在ALS中经常被忽视的因素.
- 不调节的细胞内平衡和细胞网络有助于ALS病理.
结论:
- 了解遗传和环境因素的复杂相互作用对于ALS研究至关重要.
- 针对表观遗传和表观转录学变异,为ALS提供了一个有前途的治疗途径.
- 基于多样化的分子和临床形状的患者分层对于在ALS中推进精准医学至关重要.
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