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在前列腺MRI上更难检测具有cribriform架构的前列腺腺癌吗?

Mason J Belue¹, Zoë Blake², Enis C Yilmaz¹

¹Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

|August 25, 2023

概括

活检上的尖形前列腺癌 (PCa) 可能导致MRI上的疾病程度被低估. 这项研究发现,含有CBFM的瘤的癌症产量高于基于MRI大小的预期,影响了分期.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
放射学放射学是一门学科.
病理学病理学病理学

背景情况:

前列腺活检上的Cribriform模式 (CBFM) 与高风险特征和不良结果有关.
CBFM,假阴性MRI结果和组织病理学疾病负担之间的关联需要进一步调查.

研究的目的:

为了确定是否有CBFM模式的前列腺癌 (PCa) 与假阴性MRI发现有关.
评估MRI特征与PCa与CBFM中的组织病理疾病负担之间的关系.

主要方法:

在活检和活检前多参数MRI (mpMRI) 上对131名CBFM患者的回顾性分析.
活检核的分类为良性 (C0),没有CBFM的PCa (C1) 和带有CBFM的PCa (C2).
对MRI损伤尺寸和癌症核心长度 (CCL) 的相关性分析,以及对C1和C2损伤之间的CCL进行比较.

主要成果:

针对性活检 (TBx) 在76.3%的患者中确定了CBFM,而系统活检 (SBx) 在61.1%中确定了CBFM.
无论是TBx还是SBx,在较小的前列腺中都显示了相当的检测率.
在C1和C2病变中,MRI病变大小和CCL之间发现了显著的正相关性 (p<0.01).
对于特定的MRI T2和PI-RADS得分,C2病变显示出比C1病变更大的CCL,尽管MRI尺寸相似.

结论:

含有CBFM的瘤的程度可能会被mpMRI低估.
阳性CBFM瘤可以在活检上产生比MRI病变大小建议的更高的癌症负担.
准确的mpMRI估计对于分期和治疗规划至关重要;特别考虑CBFM模式是合理的.

关键词:

癌症核心长度癌症核心长度形形状的图案形状的图案多参数核磁共振成像前列腺癌是前列腺癌.

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