一个基于机器学习的模型来预测肺癌患者的住院死亡率:对523,959例患者的基于人口的研究
Que N N Tran1, Minh-Khang Le2, Tetsuo Kondo2
1Emergency & Critical Care Medicine Department, Graduate School of Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi Prefecture, 1110 Shimokato, Chuo City 409-3898, Japan.
Advances in respiratory medicine
|August 25, 2023
概括
这项研究开发了一种模型,用于预测新肺癌患者的住院死亡风险. 该工具将患者分为高风险和低风险组,以帮助临床决策和治疗规划.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 肺癌患者需要对住院死亡率进行风险分层.
- 预测模型可以帮助早期识别高风险个体.
研究的目的:
- 开发和验证新诊断的肺癌患者住院死亡率的预测模型.
- 为了改善临床管理,将患者分为不同的风险组.
主要方法:
- 来自监测,流行病学和最终结果 (SEER) 数据库的522,941例肺癌病例的分析.
- 使用年龄,性别,瘤大小,T,N和AJCC阶段开发后勤回归模型.
- 培训和验证数据集的内部验证,使用癌症基因组图谱 (TCGA) 数据进行外部验证.
主要成果:
- 该模型在培训和内部验证队伍中显示出高的歧视力,曲线下的面积 (AUC) 为0.78.
- 外部验证给出了0.759的AUC,表明了良好的概括性.
- 为了实际的临床使用,创建了一个名录图,网络应用程序和风险表.
结论:
- 开发的模型有效地根据住院死亡风险对肺癌患者进行了分层.
- 这个工具可以帮助临床医生做出明智的决策,为患者的护理和规划.
- 该模型为肺癌管理中的个性化风险评估提供了宝贵的资源.
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