基于纳米粒子的治疗方法治疗皮肤癌:系统性审查
Michael Joseph Diaz1, Nicole Natarelli2, Shaliz Aflatooni2
1College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Current oncology (Toronto, Ont.)
|August 25, 2023
概括
纳米粒子通过改善药物输送和降低毒性,在治疗皮肤癌方面表现有前途. 需要进一步的研究,因为皮肤癌的纳米配方落后于其他癌症类型.
科学领域:
- 在瘤学瘤学.
- 纳米技术纳米技术
- 皮肤病学 皮肤病学
背景情况:
- 纳米粒子在癌症治疗中具有作为抗瘤剂和药物载体的潜力.
- 临床瘤学面临的局限性是由于低成功率和毒性,尽管免疫调节的进展.
研究的目的:
- 审查药物输送纳米颗粒用于全身和局部皮肤癌治疗的进展.
- 评估纳米颗粒在皮肤癌临床前和临床环境中的疗效和特性.
主要方法:
- 对受控试验,元分析和Cochrane评论的系统审查.
- 纳入标准集中在纳米粒子对皮肤癌的实用性,治疗结果,受试者群体和英语全文文章.
- 分析了43篇被选中的文章.
主要成果:
- 纳米系统表现出显著的抗瘤和抗转移性质,包括提高药物的生物可用性,降低毒性和改善瘤生长抑制.
- 纳米颗粒药物递送系统证明了增强的透性和保留效应.
- 新出现的证据强调了纳米颗粒在向原发性和转移性皮肤癌症方面的潜力.
结论:
- 纳米颗粒对通过改善药物输送和向治疗来推进皮肤癌治疗具有重大前景.
- 尽管它们具有潜力,但与其他癌症类型相比,皮肤癌的纳米配方开发程度较低.
- 纳米配方的进一步开发和临床转化对于克服皮肤癌治疗当前的局限性至关重要.
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