化疗对老年胆道癌症患者的安全性和有效性 胆道癌症患者
Takeshi Okamoto1, Tsuyoshi Takeda1, Takashi Sasaki1
1Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
Current oncology (Toronto, Ont.)
|August 25, 2023
概括
老年胆道癌 (BTC) 患者的化疗对单疗和组合疗法的结果类似. 单疗是选择老年BTC患者的可行选择,具有较低的毒性率.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 胃肠病学 胃肠病学
背景情况:
- 化疗在患有胆道癌症 (BTC) 的老年患者中的作用尚不清楚.
- 关于这种人群中不同化疗方案的安全性和疗效的数据有限.
研究的目的:
- 为了评估化疗在老年患者 (≥75岁) 的安全性和有效性,晚期或复发性BTC.
- 为了比较接受BTC化疗的老年人和非老年患者之间的结果.
主要方法:
- 在2016年1月至2021年12月期间接受治疗的283名BTC患者的回顾性评估.
- 分析化疗方案,毒性概况,治疗中止和整体存活率 (OS).
- 老年人 (≥75岁) 和非老年患者组之间的结局比较.
主要成果:
- 老年患者更有可能接受单一治疗 (gemcitabine或S-1),并经历较少的3-4级毒性.
- 由于不耐受性而终止治疗和过渡到二线化疗在各年龄组之间是相似的.
- 在老年患者中,组合疗法显示了比单疗法更长的中位数生存期,但单疗法不是生存的独立预测因素.
结论:
- 用gemcitabine或S-1单疗是一种安全且潜在有效的选择,可供选择的老年BTC患者使用.
- 年龄不是总体BTC队列总体生存的独立预测因素.
- 虽然组合疗法可以为老年患者提供生存益处,但单一疗法仍然是一个可行的替代方案,特别是考虑到毒性.
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