新型细胞和免疫疗法:毒性和外科手术期间的影响
Alessandro De Camilli1, Gregory Fischer1
1Memorial Sloan Kettering, 1275 York Avenue, New York, NY 10065, USA.
Current oncology (Toronto, Ont.)
|August 25, 2023
概括
新的癌症免疫疗法精确地准恶性细胞. 了解它们独特的毒性对于经过这些先进治疗的癌症患者的外科提供者来说至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 麻醉学 麻醉学
背景情况:
- 向细胞和免疫疗法代表了癌症治疗的范式转变,与传统化疗不同.
- 这些新型药物利用免疫系统摧毁癌细胞并克服瘤免疫逃避.
- 它们独特的机制可以导致明显的急性和慢性毒性,影响各种器官系统.
研究的目的:
- 为外科外科提供者提供有关新型癌症免疫疗法的机制的信息.
- 突出这些新兴治疗方法的急性和亚急性毒性概况.
- 强调最新知识对于在外科手术期间治疗癌症患者的重要性.
主要方法:
- 对针对性细胞和免疫疗法的当前文献的综述.
- 分析已知的毒性概况及其临床表现.
- 讨论对外科手术期间管理的影响.
主要成果:
- 免疫疗法增强T细胞识别和向瘤抗原.
- 毒性包括肠炎,肺炎,肝炎和肝炎,这些疾病可以模仿其他疾病.
- 这些毒性显著影响外科手术期间的发病率,需要具体的管理考虑.
结论:
- 周围手术提供者必须了解免疫疗法机制和毒性.
- 意识到与免疫疗法相关的毒性对于优化术后护理和患者结果至关重要.
- 接受免疫治疗的患者需要主动管理,包括查和预防.
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