在非水溶液中制备和描述N,N-二甲基烯胺-二甲基酸酸凝/水凝
Md Murshed Bhuyan1, Mobinul Islam2, Jae-Ho Jeong1
1Thermal-Fluid Energy Machine Lab., Department of Mechanical Engineering, Gachon University, 1342, Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Gels (Basel, Switzerland)
|August 25, 2023
概括
新的N,N-二甲基烯胺-二甲基酸 (DMAA-DAM) 凝用玛辐射在二甲基硫氧化物 (DMSO) 中进行了合成. 这些凝显示出非水性药物输送应用的潜力.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 非水性凝对于特定的肠道药物释放至关重要.
- N,N-Dimethyl acrylamide-Diallyl Maleate (DMAA-DAM) 为新型凝配方提供了潜在的可能性.
研究的目的:
- 使用玛辐射在二甲基硫氧化物 (DMSO) 中制备和描述DMAA-DAM凝.
- 为了评估不同的玛辐射剂量对凝性质的影响.
- 评估DMAA-DAM凝对于药物输送的适用性.
主要方法:
- 在DMSO中的DMAA-DAM被照射在2,5,10,20和30kGy的剂量中,使用一个Co-60马源.
- 进行了凝含量,平衡胀,FTIR,NMR,DSC,TGA和XRD分析.
- 描述的重点是功能组,质子环境,热稳定性和晶体性质.
主要成果:
- 所有辐射剂量都导致凝含量超过95%,在10kGy时为97%.
- 在5kGy剂量时,优化的平衡胀达到1800%.
- FTIR和NMR证实了凝的形成;DSC/TGA表示在86.55°C时发生玻璃化,在320°C时开始降解.
- XRD显示了一种半晶体结构.
结论:
- 通过玛辐射合成的DMAA-DAM凝表现出有利的特性.
- 这些凝显示出作为非水性药物递送系统的可行矩阵的潜力.
- 需要进一步的研究来探索它们在向性肠道药物释放中的应用.
相关概念视频
01:29Preparation of Amides
Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
01:12Preparation of Nitriles
One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...