KLVFF结合黄素微乳液基水凝用于鼻腔通道:配方开发,优化,物理化学表征和活体评估
Rungsinee Phongpradist1, Jutamas Jiaranaikulwanitch1, Kriangkrai Thongkorn2
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
这项研究开发了一种基于库尔库明微乳液的KLVFF结合水凝,用于通过鼻子输送治疗阿尔茨海默病. 优化的水凝显示出改善的粘膜粘附性和减少的鼻腔毒性,提供了一个有希望的药物输送策略.
科学领域:
- 制药科学 制药科学
- 神经科学是一个神经科学.
- 生物材料是一种生物材料.
背景情况:
- 黄素显示出对阿尔茨海默病 (AD) 治疗的潜力,但其生物可用性较差,血脑屏障透.
- 透鼻分娩提供了另一种途径,但快速的粘膜清除限制了药物接触时间.
- 开发粘膜粘合系统对于提高鼻腔药物保留和有效性至关重要.
研究的目的:
- 为了优化KLVFF结合的库尔库微乳液基水凝 (KCMEG) 通过鼻子给药.
- 改善曲素配方的粘膜粘合性,以增强鼻腔药物输送.
- 为了评估优化KCMEG的物理化学特征和安全性,用于潜在的AD治疗.
主要方法:
- 利用响应表面方法与中央复合材料设计,以优化碳醇940度和KLVFF结合黄素微乳液 (KCME) 百分比.
- 研究KCME的物理化学特性,抗胆化酶和抗聚合活性.
- 通过使用猪鼻粘膜对pH,扩散性,粘膜粘合和ex vivo鼻毒性进行了优化KCMEG的评估.
主要成果:
- 优化过程显著影响了硬度和粘度 (p < 0.05).
- 优化的KCME (70.8 ± 3.4纳米,pH 5.80 ± 0.02) 被编制成KCMEG.
- 优化的KCMEG (2%碳醇940) 在体外表现出优异的粘粘性潜力 (9.67±0.13分钟),并被发现是非毒性.
结论:
- 结合粘膜粘合剂可以提高鼻腔配方的保留时间.
- 优化的KCMEG显示出改善黄素向大脑输送的显著潜力.
- 在阿尔茨海默氏病的鼻腔治疗中,KCMEG是一个有前途的策略.
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