功能化聚氨的合成和评估,用于慢性伤口中对pH响应的化合物的递送
Zhongyan Li1, Matthew Crago1, Timothy Schofield1
1Faculty of Engineering, School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
Gels (Basel, Switzerland)
|August 25, 2023
概括
灵活的响应pH的水凝是使用阴离子和阴离子聚氨来开发的,用于慢性伤口治疗. 这些材料展示了可调节的药物释放,影响了对常见伤口病原体的抗菌疗效.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 慢性伤口通常存在由于细菌感染导致的异常pH值.
- 现有的治疗方法可能受到伤口环境的pH依赖性限制.
- 响应pH的药物输送系统为有针对性的治疗应用提供了一个有希望的方法.
研究的目的:
- 开发灵活的,对pH值有反应的水凝,用于在慢性伤口环境中向药物输送.
- 调查阴离子和阴离子功能化对水凝特性和药物释放动力学的影响.
- 评估含有抗生素的水凝对相关伤口病原体的抗菌疗效.
主要方法:
- 水友性聚氨被用聚乙烯胺 (阴性) 或酸 (阳性) 部分功能化.
- 由此产生的水凝膜的物理化学表征,包括在不同pH值下进行表面电荷分析.
- 将模型化合物和西普洛素加载到水凝中,以评估pH取决于释放的配置.
- 在体外使用黄金葡萄球菌和大肠杆菌的抗菌试验.
主要成果:
- 证实水凝表面电荷依赖于pH值,与缓冲器pH值相关.
- 水凝骨干和加载化合物之间的静电相互作用决定了释放速度.
- 阴离子和阴离子水凝对普洛克萨具有不同的释放特征.
- 不同的释放特征导致对S. aureus和E. coli产生不同的抗菌作用.
结论:
- 阴离子和阴离子的水友聚氨显示出作为慢性伤口治疗的灵活的pH响应材料的潜力.
- 可调节的药物释放特性能够根据伤口pH调节抗菌活性.
- 这些材料为先进的伤口管理策略提供了一个有前途的平台.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...