阿尔及利亚工人暴露于真菌毒素-生物监测研究
Marta I Mendes1, Sara C Cunha1, Iméne Rebai2
1LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
概括
这项研究监测了阿尔及利亚工人的多种真菌毒素水平,发现了广泛的污染. 毒素-2 (T-2),泽拉伦 (ZEN) 和 ochratoxin A (OTA) 是普遍存在的,突出了风险评估和监管的需要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 菌毒素是真菌的二次代谢产物,对人类和动物构成健康风险.
- 对毒素暴露的生物监测对于公共卫生风险评估至关重要.
- 阿尔及利亚之前缺乏基于人口的真菌毒素暴露数据.
研究的目的:
- 为了确定阿尔及利亚工人的尿液中的多种真菌毒素水平.
- 开发和验证一种用于检测真菌毒素的敏感分析方法.
- 为了确定这个人群中菌毒素暴露的基线数据.
主要方法:
- 一个QuEChERS (快速,容易,便宜,有效,坚固,安全) 的提取方法被优化.
- 液体染色学-并联质谱法 (LC-MS/MS) 用于检测.
- 在96个尿样中量化了11种真菌毒素.
主要成果:
- 所有的尿样都显示了至少两种真菌毒素的同时暴露.
- 在92.7%的样本中检测到毒素-2 (T-2),其次是泽拉伦 (ZEN) (90.6%) 和 ochratoxin A (OTA) (86.4%).
- 检测到的T-2,OTA和ZEN水平处于特定范围内 (例如,T-2:0.336.3μg/L).
结论:
- 这是阿尔及利亚对真菌毒素的第一个生物监测研究.
- 这些发现强调了受研究人群中显著的真菌毒素暴露.
- 结果强调需要改进风险评估和监管策略.
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