男人激素治疗的长期结果:一项T4DM随机化后观察性随访研究
David J Handelsman1, Mathis Grossmann2, Bu B Yeap3,4
1ANZAC Research Institute, University of Sydney and Department of Andrology, Concord Hospital, Sydney, NSW 2139, Australia.
The Journal of clinical endocrinology and metabolism
|August 25, 2023
概括
在研究期间,在糖尿病前期或新糖尿病的男性接受激素治疗,糖尿病诊断减少了40%. 长期随访显示,在停止治疗后,糖尿病,心血管或前列腺疾病的诊断没有显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 男人的健康 男人健康
背景情况:
- 在T4DM研究中,研究了素未酸 (TU) 对葡萄糖耐受性受损或新发糖尿病的男性的影响.
- 关于糖尿病,心血管疾病,前列腺健康和雄激素依赖的长期结果以前没有详细说明.
研究的目的:
- 评估24个月的治疗对糖尿病发病率,心血管和前列腺疾病,睡眠呼吸暂停,体重控制和雄激素依赖的长期影响.
- 评估参与者报告的益处和研究后的治疗坚持.
主要方法:
- 1007名患有葡萄糖耐受性损害或新型糖尿病的男性被随机分配给TU或安慰剂注射,每12周注射一次,持续24个月,并进行一种生活方式计划.
- 在最后一次注射后平均5.1年进行了后续电子邮件调查,有599名参与者完成了调查.
主要成果:
- 在研究期间,激素治疗减少了40%的糖尿病诊断.
- 在TU治疗期间,睡眠呼吸暂停的诊断更频繁 (3.0%对0.4%),但在研究后并不如此.
- 在研究后,在TU组中恢复处方丸激素治疗的频率更高 (6%vs2.8%).
- 停止TU五年后,在自我报告的糖尿病,前列腺或心血管疾病的新诊断以及体重管理行为中没有观察到任何差异.
结论:
- 在患有糖尿病前期或新糖尿病的男性中,随机24个月的丸激素治疗与治疗期间感知到的益处和睡眠呼吸暂停诊断增加有关.
- 在研究后,处方治疗恢复率较高表明一些男性的雄激素依赖性.
- 长期随访表明,在停止治疗后,主要健康结果没有持续的差异.
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