对从急性COVID-19疾病中康复的患者进行心声评估
Luke Stefani1,2, Paula Brown2, Monica Gerges2
1Westmead Clinical School, Westmead Hospital, University of Sydney, Westmead 2145, Australia.
Journal of cardiovascular development and disease
|August 25, 2023
概括
COVID-19 感染可能会导致持久的心血管问题,影响左心室和右心室功能. 心声扫描显示,在康复的患者中,无论COVID-19的初始严重程度如何,心室应变减少.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 新型冠状病毒 (COVID-19) 感染是一个重大的全球公共卫生挑战.
- 心血管系统并发症可以在急性COVID-19感染期间和感染后的时期出现.
- 在COVID-19后持续的症状需要了解其长期的心血管影响.
研究的目的:
- 在COVID-19幸存者中评估左心室 (LV) 和右心室 (RV) 功能,使用心声学.
- 为了比较从COVID-19中恢复过来的患者和健康对照之间的心声学参数.
- 调查COVID-19对心肌菌株的影响,特别是LV全球纵向菌株 (GLS) 和RV无壁菌株 (FWS).
主要方法:
- 对42名COVID-19康复患者进行了回顾性观察性横截面研究,这些患者的症状仍在持续.
- 患者在诊断后112天的中位数接受了综合性心声回声.
- 测量了高级心声回声学参数,包括2D LV GLS和RV FWS,并与年龄和性别匹配的健康对照进行了比较.
主要成果:
- 在不同组中,LV喷射分数和RV体积/功能是相似的.
- 与对照组相比,在COVID-19幸存者中观察到明显减少的LV GLS (p=0.002) 和RV FWS (p=0.009).
- 这些菌株异常存在于住院和非住院患者中,并且独立于并发症.
结论:
- 之前的COVID-19感染与亚临床LV功能障碍有关,减少LV GLS表明,即使在没有并发症的患者中也是如此.
- 在康复的COVID-19患者中异常的腹腔应变表明持久的心血管影响,无论最初的感染严重程度如何.
- LV GLS可以作为一种有价值的临床工具,用于识别潜在的COVID-19相关心肌炎,并指导进一步的心脏成像.
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