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Updated: Jul 18, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Published on: January 7, 2019

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瘤基因诱导的MALT1蛋白酶活性驱动恶性淋巴瘤中的转录后基因表达

Nicole Wimberger1, Franziska Ober1, Göksu Avar2,3

  • 1Research Unit Signaling and Translation, Group Signaling and Immunity, Molecular Targets Therapeutic Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Blood
|August 25, 2023
PubMed
概括

粘膜相关的淋巴组织淋巴瘤转位蛋白1 (MALT1) 蛋白酶活性,而不是脚手架,通过裂解RNA结合蛋白来驱动淋巴瘤. 这种MALT1蛋白酶功能调节了关键的生存基因,为新的淋巴瘤疗法提供了标.

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