肺功能障碍的纵向分析 一年后的COVID-19:一个单中心研究
Noemi Suppini1,2,3, Ovidiu Fira-Mladinescu1,2, Daniel Traila1,2
1Discipline of Pulmonology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Journal of personalized medicine
|August 25, 2023
概括
在COVID-19后的持续性肺功能障碍可以在一年内改善. 肺功能,特别是肺部对一氧化碳的扩散能力 (DLCO) 和肺部总容量 (TLC),显著恢复,特别是在严重的COVID-19病例中.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 在COVID-19感染后持续性肺功能障碍是一种已知的并发症,报告的严重程度不同.
- 了解COVID-19后肺功能恢复的长期轨迹对于患者管理和康复策略至关重要.
研究的目的:
- 在康复一年后,对COVID-19幸存者的肺功能进行纵向评估.
- 评估肺功能变化,COVID-19疾病严重程度和先前存在的肺部疾病之间的关联.
主要方法:
- 这是一项单一中心的观察性研究,涉及140名年龄在18岁及以上的COVID-19幸存者.
- 肺功能使用螺旋计 (测量1秒强制呼吸量[FEV1],强制生命能力[FVC],肺总容量[TLC]) 和肺部对一氧化碳 (DLCO) 扩散能力的测试来评估.
- 参与者根据疾病严重程度 (轻度,中度,严重) 进行了分层分类,并通过计算机断层扫描 (CT) 评估纤维变化.
主要成果:
- 后COVID纤维化与疾病严重程度显著相关 (p=0.003),在51.9%的严重病例中观察到.
- 随着疾病的严重程度 (p<0.001),强迫生命能力 (FVC) 显著下降,肺总容量 (TLC) 和残留体积 (RV) 也显著下降.
- 感染后一年,DLCO (p=0.010) 和TLC的显著改善,严重COVID-19患者的病情得到了实质性的恢复.
结论:
- 在感染后一年的COVID-19疾病严重程度和COVID后纤维化变化之间存在显著的关联.
- 虽然一些肺功能参数保持稳定,但DLCO和TLC的显著改善表明肺损伤的潜在可逆性.
- 患有严重COVID-19的患者在一年内表现出相当大的肺功能恢复,这表明肺部康复的预后是积极的.
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