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个性化医学在癌症疼痛管理中的个人化医学
Mohammad Raad1, William Omar Contreras López2,3, Alireza Sharafshah4
1Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Journal of personalized medicine
|August 25, 2023
概括
个性化医学和药物基因组学为管理癌症疼痛提供了新的途径. 本次审查确定了针对量身定制的治疗策略的关键基因和生物标志物,以改善患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 药物基因组学 药物基因组学
- 疼痛管理 疼痛管理
背景情况:
- 癌症疼痛显著影响患者的生活质量.
- 有效的癌症疼痛管理 (CPM) 是至关重要的.
- 在CPM中,个性化医疗方法正在出现.
研究的目的:
- 系统地审查CPM策略,专注于个性化医疗.
- 为癌症疼痛检测和治疗引入基于药物基因组学的方法.
主要方法:
- 使用关键词:癌症,疼痛,个性化医学. PubMed (1990-2023) 的系统文献综述.
- 在使用GeneCards,STRING-MODEL,miRTargetLink2和PharmGKB数据库进行的in silico分析.
- 在过了597个初始结果后,包括了75个相关出版物.
主要成果:
- 个性化医学和药物基因组学越来越多地成为CPM的核心.
- 确定了57个基于证据的基因 (例如,CYP2D6,COMT,OPRM1) 用于个性化的方法.
- 发现了21种潜在的全外因子测序变异,并建议hsa-miR-34a-5p/hsa-miR-146a-5p作为生物标志物.
结论:
- 由药物基因组学驱动的个性化医学是有效的CPM最有前途的策略.
- 药物基因组学使量身定制的治疗方法能够缓解癌症疼痛.
- 鉴定出基因和生物标志物为先进的癌症疼痛管理铺平了道路.
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