患有急性失补心力衰竭和铁缺乏症的患者的铁碳糖糖:现实生活中的研究
Federico Capone1, Alberto Cipriani2, Leonardo Molinari1
1Department of Medicine (DIMED), University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.
Journal of personalized medicine
|August 25, 2023
概括
在急性不补偿性心力衰竭 (ADHF) 中,用铁性碳糖糖 (FCM) 治疗缺铁 (ID) 需要达到目标剂量和门诊随访以获得临床益处. 在这个ADHF队列中,不适当的剂量和短期治疗没有纠正ID或改善结果.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺铁 (ID) 是心力衰竭 (HF) 中常见的并发症,其喷射分数减少.
- 铁性碳酸盐糖 (FCM) 是一种推用于治疗HF的ID的治疗方法.
- 在急性不补偿性心力衰竭 (ADHF) 中,ID查和FCM治疗的临床意义需要在现实世界中进行评估.
研究的目的:
- 评价铁缺乏症查和铁性碳酸治疗在急性不补偿性心力衰竭 (ADHF) 患者中的实际临床意义.
主要方法:
- 一组104名ADHF患者的铁状况被评估.
- 在81.1%的患者 (n=73) 中检测到缺铁.
- 55名患者在医院接受了铁性碳酸盐糖 (FCM),只有13人达到目标剂量.
主要成果:
- 在接受FCM补充剂和未补充剂的患者之间,没有观察到死亡率或再住院率的显著差异.
- 在随访时,75%的接受FCM治疗的患者和69.2%未接受治疗的患者的铁缺乏症持续存在.
- 只有14.5%的FCM补充患者在出院后继续接受治疗.
结论:
- 在这个现实世界的ADHF队列中,铁性碳酸 (FCM) 往往是低剂量,并没有有效地纠正缺铁.
- 达到目标FCM剂量和确保门诊治疗对于纠正缺铁和在ADHF患者中获得长期临床益处至关重要.
- 目前在ADHF中使用FCM的现实实践可能不会产生预期的临床改善.
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