在内镜喉外科手术中,对实时组织学评估的vivascope的潜在使用
Luigi De Benedetto1, Antonio Moffa1,2, Peter Baptista3,4
1Unit of Integrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Rome, Italy.
Journal of personalized medicine
|August 25, 2023
概括
同焦激光扫描显微镜 (CLSM) 提供了一种可行的实时检查喉病变的方法. 这种技术与确定的组织病理学结果有很好的一致性,有助于进行手术决策.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病理学 病理学 病理学
- 医疗成像医学成像
背景情况:
- 对喉病变的准确实时评估对于内镜手术至关重要.
- 传统的组织病理学需要样本处理,延迟最终的诊断.
研究的目的:
- 评估共聚焦激光扫描显微镜 (CLSM) 的可行性,用于喉病变的体外检查.
- 评估CLSM发现与最终的遗传病理学结果之间的相关性.
主要方法:
- 一项初步研究涉及八名疑似喉病变的患者.
- 使用CLSM检查出活体组织学样本.
- 将CLSM的发现与确定的组织病理学结果进行了比较.
主要成果:
- CLSM提供了所有样本的宏观图像和数字版本.
- 所有样本被CLSM认为充足,并通过组织病理学证实.
- 组织病理学揭示了低度的发育不良 (n=5),混合的低度和高度发育不良 (n=2),以及高度发育不良 (n=1).
- 四个样本涉及切除边缘,三个显示炎症爆发.
结论:
- CLSM是一种可行的技术,可以实时对喉病理进行体外检查.
- CLSM显示出与最终组织学诊断的良好一致.
- 这种方法有可能改善喉外科手术中的手术内决策.
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