作为缺铁生物标志物的可溶性转移林受体:对心力衰竭患者的运动能力的影响
Maria Del Mar Ras-Jiménez1,2,3, Raúl Ramos-Polo1,2,4, Josep Francesch Manzano1
1Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L'Hospitalet de Llobregat, Spain.
Journal of personalized medicine
|August 25, 2023
概括
在心力衰竭患者中,铁含量正常,可溶性转激素受体 (sTfR) 的升高表明组织缺铁. 这种缺陷与运动能力降低和生活质量 (QoL) 降低有关.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 生物化学 生化学
背景情况:
- 溶性转移素受体 (sTfR) 反映了组织对铁的需求.
- 组织铁状况对正常全身铁的心力衰竭 (HF) 患者的影响尚不清楚.
- sTfR可能表明非贫血HF患者的功能能力和生活质量 (QoL) 问题.
研究的目的:
- 为了评估sTfR水平和功能能力 (6分钟步行测试,6MWT) 和QoL (明尼苏达生活心力衰竭问卷,MLHFQ) 在非贫血的HF患者与正常的全身铁之间的关联.
- 为了确定是否升高的sTfR,表明组织缺铁,影响运动能力和QoL在这个患者群.
主要方法:
- 这是一项对1236名慢性HF患者的观察性前性队列研究.
- 选择了215名血红蛋白正常和全身铁状况正常的患者.
- 组织铁缺乏症定义为75百分位以上的sTfR水平 (> 1.63 mg/L).
- 评估的主要终点:6MWT距离和MLHFQ总体总结得分 (OSS).
主要成果:
- 组织铁缺乏症患者 (较高的sTfR) 的QoL明显较差 (51 ± 27对39 ± 20,p=0.006).
- 组织铁缺乏症患者的6MWT距离显著缩短 (206 ± 179 m与314 ± 155 m相比,p<0.0001).
- 更高的sTfR水平与更短的6MWT距离 (β=-0.249,p<0.001) 和更高的MLHFQ OSS (β=0.183,p=0.008) 相相关.
结论:
- 患有正常全身铁的高血压患者的sTfR水平升高与下极限运动能力受损密切相关.
- 较高的sTfR水平与这种特定HF人群的生活质量差异相关.
- sTfR可以作为组织铁状况的有价值指标,影响心力衰竭的功能结果.
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