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抗生素抗生素自身抗体和真菌感染

Shanthi Kappagoda¹, Stanley Deresinski¹

¹Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94304, USA.

Journal of fungi (Basel, Switzerland)

|August 25, 2023

概括

抗生素自抗体 (ACAA) 导致成人开始的免疫缺陷,导致严重的真菌感染. 识别ACAA对于诊断和管理这些罕见但严重的疾病至关重要.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
遗传学遗传学是一个

背景情况:

成年开始的免疫缺陷可以模仿原发性疾病.
严重的真菌感染可能表明潜在的免疫失调.
抗生素自身抗体 (ACAA) 越来越多地被认为是获得性免疫缺陷的原因.

研究的目的:

审查先天免疫和细胞因子在真菌感染中的作用.
提出临床病例,将ACAA与严重的真菌感染联系起来.
讨论ACAA相关疾病的诊断测试和治疗策略.

主要方法:

关于天生的免疫和真菌感染的文献综述.
对四名患有ACAA和严重真菌感染的患者的病例系列分析.
对ACAA和治疗选择的诊断试验的讨论.

主要成果:

详细介绍了四种不同的临床情景:抗干扰素-γ与Talaromyces marneffei和基因质;抗GM-CSF与Cryptococcus gattii;抗IL-17A/F与粘膜皮肤候群病.
在这些情况下,ACAA与耐火性和严重的真菌感染有关.
这项研究强调了在无法解释的免疫缺陷中考虑ACAA的重要性.

结论:

通过破坏关键的细胞因子通路,ACAA可以导致严重的,危及生命的真菌感染.
在患有严重或复发性真菌感染和免疫缺陷症状的患者中,应考虑对ACAA进行测试.
针对性治疗,既针对感染,也针对自身抗体的产生,对于管理至关重要.

关键词:

抗基因转基因-CSF抗体.对抗IL-17/22的抗体.抗干扰素-γ 抗体.抗生素抗生素自身抗体抗生素自身抗体慢性粘膜皮肤候群病.这种疾病叫做cryptococcosis.基因质子体的发生 histoplasmosis.塔拉罗米科西斯是一种发病性疾病.

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