抗候性海洋天然产品:一篇综述
Arumugam Ganeshkumar1,2, Juliana Caparroz Gonçale1, Rajendran Rajaram3
1Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University (UNESP), Sao Jose dos Campos 12245-000, Brazil.
Journal of fungi (Basel, Switzerland)
|August 25, 2023
概括
海洋天然产品在对抗 Candida 感染方面表现有前途,包括耐药菌株. 海绵产生的化合物,如hippolide J,提供了新的治疗途径对候群病.
科学领域:
- 海洋生物学 海洋生物学
- 微生物学 微生物学
- 自然产品化学 自然产品化学
背景情况:
- * *Candida*物种是机会性病原体,会引起感染,特别是在免疫力低下的个体中.
- * *Candida albicans*是最常见的物种,但像*Candida auris*这样的耐药菌株构成越来越大的威胁.
- *抗真菌耐药性限制了候群病的治疗选择.
研究的目的:
- * 审查海洋自然产品在控制*Candida*物种繁殖和代谢方面的潜力.
- *以突出显示具有抗候性活性的海洋生物和化合物.
- * 探索海洋产品的作用机制和协同效应.
主要方法:
- *自20世纪80年代以来,对海洋天然产品及其抗候群活性研究的文献综述.
- *分析来自海绵,藻类,海黄瓜,细菌和真菌的化合物.
- * 检查特定的化合物,如海绵Hippospongia lachne*中的hippolide J.
主要成果:
- *海洋天然产品,特别是来自海绵的产品,对包括耐药菌株在内的各种*Candida*物种表现出显著的抑制活性.
- *海绵中的类化合物,类化合物和类化合物是强大的抗候选性药物.
- *Hippolide J对*Candida albicans*,*Candida parapsilosis*和*Candida glabrata*表现出强烈的活动.
结论:
- *海洋衍生化合物可以有效控制*Candida*属的微生物.
- * 这些天然产品为开发新型抗候群疗法提供了有希望的来源.
- * 对机制和协同作用的进一步研究可以指导新药设计.
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