粘性菌根症:黎巴嫩的一家三级护理中心的14年回顾性研究
Fatima Allaw1, Johnny Zakhour1, Sarah B Nahhal1
1Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut Medical Center, Beirut 110236, Lebanon.
Journal of fungi (Basel, Switzerland)
|August 25, 2023
概括
在COVID-19大流行期间,菌菌病 (MCM) 病例显著增加,特别是在免疫功能低下的患者中. 早期诊断,治疗和手术可以提高这种侵袭性真菌病的生存率.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 流行病学 流行病学
背景情况:
- 粘菌菌病 (MCM) 是一种严重的侵入性真菌病 (IFD),死亡率高,特别是在免疫受损的个体中.
- 全球MCM病例的增加与COVID-19大流行相吻合.
研究的目的:
- 为了分析14年来黎巴嫩的第三级护理中心MCM的发病率,季节性变化,临床特征和死亡率预测因素.
- 评估COVID-19大流行对MCM发病率的影响.
主要方法:
- 从2008年1月到2023年1月,对所有已证实或可能发生的MCM病例进行了回顾性图表审查.
- 纳入标准:MCM的阳性基因病理学和/或培养.
- 数据分析包括发病率,人口统计,临床特征,治疗和结果.
主要成果:
- 总共有43名MCM患者被确定,平均年龄为53岁;58.1%是男性.
- 大多数病例发生在秋季. 血液性恶性瘤 (67.4%) 和不受控制的糖尿病 (34.9%) 是常见的并发病.
- 犀牛轨道大脑MCM (ROCM) 是最常见的表现 (74%). 在2020-2021年期间,每10万患者日的MCM发病率从0上升到7.5,而在2020-2021年,每10万患者日的MCM发病率从0上升到7.5.
- 脂质体安福特里辛B是主要的治疗方法 (86%). 手术除菌和隔离的ROCM与更好的生存率有关.
- 所有原因的死亡率为46.7%,慢性病是死亡率的重要预测因素.
结论:
- 该机构的MCM发病率有所增加,特别是自COVID-19大流行以来.
- 早期诊断,及时使用抗真菌药物治疗和手术干预对于改善患者的治疗结果至关重要.
- 识别慢性病等危险因素对于有针对性的管理和降低死亡率至关重要.
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