在重症监护机构的Candida auris:在葡萄牙报告的第一例病例
João Henriques1, Verónica Mixão2, Joana Cabrita1
1Intensive Care Medicine Department, Centro Hospitalar Universitário Lisboa Central, 1150-199 Lisbon, Portugal.
Journal of fungi (Basel, Switzerland)
|August 25, 2023
概括
葡萄牙首例Candida auris (一种关键的真菌病原体) 病例涉及从安哥拉转移的患者. 这种隔离物表现出醇耐药性,属于基因基因III,突出显示了医院监测的必要性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 黄是一种新兴的机会性真菌病原体,在全球范围内引起广泛的医院病例.
- 世界卫生组织将Candida auris确定为关键优先病原体,因为其耐药性模式和公共卫生威胁.
- 在重症监护室 (ICU) 中,鼻腔感染带来了重大挑战,特别是在免疫功能低下的患者中.
研究的目的:
- 报告在葡萄牙发现的第一个Candida auris病例.
- 鉴定出Candida auris分离的抗真菌易感性和遗传特征.
- 调查这个病例在医院环境中的潜在起源和影响.
主要方法:
- 从支气管支气管洗中分离和识别Candida auris.
- 抗真菌敏感性测试 (AFST) 用于确定耐药性模式.
- 全基因组测序 (WGS) 用于遗传学分析和分类确定.
主要成果:
- 葡萄牙首例Candida auris病例是在从安哥拉转移的病人身上发现的.
- 隔离物对醇抗真菌剂的敏感性较低.
- 遗传学分析将该分离物置于基因分类III内,与非洲菌株密切相关.
结论:
- 这一案例凸显了Candida auris进口和通过各国之间的患者转移传播的潜力.
- 醇耐药性和III类的鉴定强调了对这种病原体的警监测的重要性.
- 医疗机构的持续监测对于有效检测和管理Candida auris感染至关重要.
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