青少年的非向代谢和身体质量:横截面和纵向分析
Amarnath Singh1, Garrett Kinnebrew2, Ping-Ching Hsu3
1Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210-1240, USA.
Metabolites
|August 25, 2023
概括
全球儿童肥胖率正在上升. 这项研究使用代谢学来识别与青少年男性体质指数 (BMI) 变化相关的尿液生物标志物,揭示了氨基酸和脂质代谢的改变.
科学领域:
- 代谢学和营养生物化学
- 儿科内分泌学和肥胖研究
背景情况:
- 全球儿童和青少年肥胖率的增加给儿童和青少年带来了重大的长期健康风险,包括慢性疾病.
- 在标准临床测量之外,对青少年体质指数 (BMI) 变化的代谢影响的了解有限.
研究的目的:
- 为了研究男性青少年的BMI变化的代谢后果,使用非向的代谢学.
- 为了确定与BMI z-score相关的潜在尿路生物标志物及其随时间变化.
主要方法:
- 使用UPLC-QTOF-MS.的360名男性青少年尿样的非目标代谢分析.
- 分析包括发现 (n=235),验证 (n=125) 和复制 (n=81,1年后续) 集.
- 线性回归模型根据年龄,种族和能量摄入量进行调整,并对错误发现率进行校正 (FDR ≤0.1).
主要成果:
- 在发现组中确定了221个显著的代谢特征,在与BMI z-score相关的验证组中确定了16个.
- 关键代谢物包括甘烯,素,硫酸,肉氨酸和L-谷氨.
- 其中9个特征与复制集中的BMI正变化相关;氨酸和氨酸代谢途径受到影响最大.
结论:
- 青少年的肥胖与尿液代谢的明显变化有关,影响了氨基酸,脂质和碳水化合物代谢.
- 已识别的代谢物可以作为肥胖及其在年轻人中的病理机制的潜在生物标志物.
- 需要进一步的研究来确定这些代谢特征是否先于BMI变化或是其结果.
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