来自病理近视患者的水性幽默的代谢分析 患有冠状动脉新血管化的患者
Qiaoling Wei1,2,3,4, Zhiqiang Yu1,2,3, Xianjin Zhou1,2,3
1Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Metabolites
|August 25, 2023
概括
在病态近视 (PM) 与胆道新血管化 (CNV) 的代谢变化被确定. 特定的代谢物,如D-酸,可以作为PM患者中CNSV的生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 冠状新血管化 (CNV) 是病理近视 (PM) 的严重并发症.
- 代谢变化可能有助于PM中CNV的发展.
研究的目的:
- 为了研究PM患者与没有CNV之间的水性幽默 (AH) 的代谢差异.
- 为了确定潜在的生物标志物和与近视CNV相关的改变代谢途径.
主要方法:
- 使用GC-MS和LC-MS对AH进行非向的代谢学分析.
- 具有CNV (n=11) 和没有CNV (n=11) 的PM患者之间的代谢物概况的比较.
- 统计分析包括ROC曲线分析和路径丰富.
主要成果:
- 检测到272种代谢物 (GC-MS) 和1457种代谢物 (LC-MS).
- 在各组之间鉴定出97种表达显著差异的代谢物.
- 突出显示D-酸,双和异氨基作为潜在的生物标志物 (AUC 0.801-1),与视网膜囊性相关.
- 揭示了12个改变的代谢途径,其中五个与碳水化合物代谢有关.
结论:
- 在AH中的特定代谢物可以作为PM中的CNV的疾病特异生物标志物.
- 乱的碳水化合物代谢与近视性CNV的发病有关.
- 需要进一步的研究来验证.
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