对来自感染性内心炎的狗的细菌分离物及其抗菌敏感性模式的调查
Alexander Schreiber1, Steven E Epstein2, Barbara A Byrne3
1VCA Animal Specialty Emergency Center, 1535 S Sepulveda Blvd, Los Angeles, CA 90025, USA.
Pathogens (Basel, Switzerland)
|August 25, 2023
概括
来自感染性内心炎 (IE) 的狗的细菌分离物通常表现出多药性耐药性 (MDR). 之前在IE犬中使用诺基诺与更高的抗药率有关,这突显了针对性抗微生物敏感性测试的必要性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 传染性内心炎 (IE) 是一种严重的,危及狗狗生命的疾病.
- 细菌病原体及其在狗IE中的抗菌素耐药性模式的表征是有限的.
研究的目的:
- 为了识别被诊断患有IE的狗的细菌分离物.
- 为了确定这些分离物的抗微生物敏感性模式.
- 评估抗微生物耐药性与生存或先前与抗微生物药物接触之间的关联.
主要方法:
- 对犬类IE病例和细菌分离物的回顾性分析.
- 使用当前的兽医截止值进行抗微生物敏感性测试.
- 统计分析以将耐药性与临床结果和治疗史相关联.
主要成果:
- 从45只狗中鉴定出51个分离物; 葡萄球菌 spp. 是最常见的 (27.5%).
- 36%的分离物体表现出多药性耐药性 (MDR).
- 之前的诺基诺暴露与非内在的诺基诺抗性 (62.5%与9.5%) 的增加有关.
结论:
- 抗菌素耐药性和MDR在狗IE中很普遍.
- 耐药性模式与这一队列的生存率没有联系.
- 对抗菌素敏感性测试对于指导IE狗的有效治疗至关重要.
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