在口腔癌中,HPV16影响NHERF2的表达
Lucija Lulić1, Antonia Jakovčević2, Iva Kovačić1
1Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.
Pathogens (Basel, Switzerland)
|August 25, 2023
概括
人类乳头瘤病毒 (HPV) 16型感染与口腔状细胞癌 (OPSCC) 有关. 研究人员发现HPV16阳性OPSCC患者的NHERF2蛋白水平下降,这表明它在癌症发展中的作用.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 人类乳头瘤病毒 (HPV) 感染,特别是HPV 16型,是口腔状细胞癌 (OPSCC) 的一个独特子集的显著风险因素.
- 阳性HPV (HPV+) 和阴性HPV (HPV-) OPSCC表现出不同的流行病学,临床和预后特征.
- 目前的研究尚未确定特定的生物标志物或独特的疗法来区分这些OPSCC亚型.
研究的目的:
- 调查HPV16阳性和HPV阴性OPSCC样本中NHERF2的表达模式.
- 为了确定NHERF2表达是否在HPV16+和HPV-OPSCC之间有所不同,以及它与瘤分化有何关联.
- 探索HPV16 E6型蛋白与NHERF2相互作用在HPV驱动的头癌发生中的潜在作用.
主要方法:
- 在HPV16+OPSCC,HPV-OPSCC和健康组织的组织样本中分析NHERF2表达模式.
- 对不同OPSCC亚型和分化度的NHERF2水平和NHERF2免疫反应性癌细胞百分比的比较.
主要成果:
- 与健康组织相比,在HPV16+ OPSCC和差异化HPV-OPSCC中观察到NHERF2水平的统计学显著下降.
- 与良好和中度差异化的HPV-OPSCC相比,HPV16+瘤显示NHERF2-免疫性癌细胞的百分比显著降低.
- 这些发现表明,HPV16 E6对NHERF2的向对HPV驱动的头部瘤发生很重要.
结论:
- 在HPV16阳性口支状细胞癌中,NHERF2的表达显著降低.
- 可能由HPV16 E6型蛋白介导的NHERF2的下调可能在HPV驱动的头癌的发展中发挥关键作用.
- 需要进一步研究NHERF2作为OPSCC的潜在生物标志物或治疗点.
关键词:
E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E6 E7 E6 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7 E7在HNSCC中,我们可以看到HNSCC.这是一个HPVHPVHPV.在NHERF2中.这是OPSCC的OPSCC.p16 p16 在这个问题上.更多相关视频
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
10.4K
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.7K
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
