模式,成本和免疫反应的MDR与MDR对比. 非MDR-细菌症:一个前性队列研究
Georgios Schinas1, Katerina Skintzi1, Anne-Lise De Lastic2
1School of Medicine, University of Patras, Rion, 26504 Patras, Greece.
Pathogens (Basel, Switzerland)
|August 25, 2023
概括
抗菌素耐药性 (AMR) 在细菌病患者中导致更糟糕的结果. 与非MDR感染相比,多抗药性 (MDR) 感染增加了死亡率,医疗费用,并引发了不同的免疫反应.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 卫生经济学 卫生经济学
背景情况:
- 抗菌素耐药性 (AMR) 是全球主要的健康威胁,使传染病管理复杂化.
- 细菌病是一个重大挑战,抗生素耐药菌株带来了更大的风险.
研究的目的:
- 为了比较免疫反应,临床结果和细菌病患者的成本,抗生素耐药的微生物与敏感的微生物相比.
- 调查多抗药性 (MDR) 细菌病对患者健康和医疗保健资源利用的影响.
主要方法:
- 2017年5月至2019年11月进行了一项单中心前性队列研究.
- 包括已被确诊的细菌病诊断的患者.
- 患有多抗药 (MDR) 和非多抗药 (非MDR) 细菌分离物的患者之间的结果比较.
主要成果:
- 分析了116名患者:63名患有MDR细菌病,53名患有非MDR细菌病.
- 患有MDR细菌病的患者表现出更严重的疾病 (更高的SOFA/APACHE II分数),更高的死亡率 (39.7%对17%),以及医疗费用增加 (€4791对€2843.5).
- 患MDR细菌病与TNF-α水平升高相关,表明有明显的免疫反应,是死亡率 (OR=3.216) 和成本增加 (27.4%的效果大小) 的独立预测因素.
结论:
- 抗菌素耐药性对医疗保健环境产生重大影响.
- 耐多药微生物带来了迫切的挑战,需要有针对性的干预.
- 解决AMR对于改善患者结果和管理医疗保健成本至关重要.
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