相关实验视频
Updated: Jul 18, 2025
10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
2.4K
长非编码RNA和结合体微RNA之间的交叉是癌症新型生物标志物
1Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Non-coding RNA
|August 25, 2023
概括
长非编码RNAs (lncRNAs) 和核微RNAs (miRNAs) 之间的相互作用可能会推动癌症的进展. 针对这些lncRNA:miRNA相互作用可以为各种癌症提供新的诊断和治疗策略.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 癌症研究 癌症研究
背景情况:
- 非编码RNAs (ncRNAs),包括微RNAs (miRNAs) 和长非编码RNAs (lncRNAs),调节细胞过程.
- ncRNAs与癌症病原发生有关,核miRNAs和lncRNAs的新兴角色正在出现.
- 最近的发现确定了癌细胞中超复合体内的miRNAs,这表明了新的相互作用.
研究的目的:
- 要突出 lncRNA 和来自相同基因组区域的核miRNA 之间的潜在交叉声.
- 探索这些相互作用在癌症,特别是乳腺癌和宫癌中的作用.
- 确定癌症诊断和治疗的新目标.
主要方法:
- 文献综述和分析潜在的RNA:RNA相互作用.
- 识别 cis 相互作用的 lncRNA:spliceosomal miRNA 配对.
- 关于 mir-7704 调节致癌的 lncRNA HAGLR. 的案例研究.
主要成果:
- 对RNA的潜力:共同表达的lncRNA和核miRNA之间的RNA基配对.
- 癌症中这些相互作用的失调可能会影响基因表达.
- 确定了mir-7704作为致癌 lncRNA HAGLR. 的负调节剂.
结论:
- lncRNA:核miRNA相互作用代表了癌症中一种新的调节机制.
- 这些相互作用,以HAGLR和mir-7704为例,可能与多种癌症类型有关.
- 准 lncRNA:核miRNA交叉对癌症治疗和诊断提供了有前途的途径.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
01:32RNA Splicing
56.5K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.5K
02:18Alternative RNA Splicing
21.3K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.3K
03:18Non-LTR Retrotransposons
11.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.6K