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CXCL17通过调节巨细胞功能来减轻柴油废气排放暴露引起的肺损伤

Yize Yin¹, Chaohui Mu², Jiahui Wang³

¹Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, School of Public Health, Qingdao University, Qingdao 266071, China.

|August 25, 2023

概括

柴油废气排放 (DEE) 会导致肺部损伤,但CXCL17

科学领域:

环境健康环境健康
免疫学免疫学免疫学
肺部医学肺部医学

背景情况:

柴油废气排放与肺部损伤有关.
巨细胞化学吸引剂CXCL17在DEE引起的肺损伤中的作用尚不清楚.

研究的目的:

研究CXCL17在DEE引起的肺损伤中的作用.
确定CXCL17是否可以成为DEE相关肺部疾病的治疗点.

主要方法:

在暴露于DEE的小鼠中,全身囊造影,炎症细胞计数和组织病理学.
对CXCL17进行基因表达分析 (qRT-PCR,IHC,ELISA).
在体外共培系统 (THP-1和HBE细胞) 与复合人类CXCL17 (rh-CXCL17).

主要成果:

暴露于DEE导致呼吸系统参数异常,呼吸道受伤和重塑.
在暴露于DEE/DEP的小鼠中,CXCL17的表达减少.
过度表达CXCL17改善了呼吸系统参数和减少了肺损伤.
rh-CXCL17增强了巨细胞迁移和减弱了呼吸道上皮细胞亡和炎症.

结论:

CXCL17在DEE引起的肺损伤方面起着保护作用.
通过招募和激活肺巨细胞,CXCL17可能会减轻肺损伤.
CXCL17是DEE相关肺部疾病的潜在治疗点.

关键词:

在C-X-C基因基因基因连接体17的C-X-C基因基因连接体17 柴油发动机的废气排放情况人类支气管呼吸道上皮细胞巨细胞是什么?巨细胞是什么?

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