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肉毒毒素-高剂量对中风患者的功能结果和性相关疼痛的影响

Domenico Intiso¹, Antonello Marco Centra¹, Michele Gravina¹

¹Unit of Neuro-Rehabilitation Unit and Rehabilitation Medicine, IRCCS 'Casa Sollievo della Sofferenza', Viale dei Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.

|August 25, 2023

概括

高剂量的甲型肉毒素 (BTX-A) 可能为一些性中风患者提供以目标为导向的改善. 然而,目前的证据不足以证实对功能结果或性相关疼痛的益处.

科学领域:

神经学神经学
康复医学康复医学康复医学
药理学药理学是指药理学的学科.

背景情况:

脑卒中经常导致性和性相关疼痛 (SRP),导致功能限制.
对严重的性建议使用更高剂量的甲型肉毒素 (BTX-A),但它们对功能和疼痛的有效性仍然不确定.

研究的目的:

评估高剂量BTX-A (≥600U) 对改善中风患者的功能结果和减少性相关疼痛 (SRP) 的有效性.

主要方法:

1989年1月至2022年12月期间在MEDLINE/PubMed,Embase和Cochrane中央注册表中发表的研究的系统审查.
仅包括obabotulinumtoxinA,onabotulinumtoxinA,和incobotulinumtoxinA. 这三种毒素.
分析了9项涉及460名受试者 (301名中风患者) 的研究.

主要成果:

只有五项研究报告了功能性结果,主要显示残疾评估量表 (DAS) 的改善.
三项研究使用视觉模拟量表 (VAS) 量化了SRP疼痛,数据不足以得出结论.
没有明确的证据支持高剂量的BTX-A可以改善四肢功能.

结论:

高剂量的BTX-A可能会为一些患有性的中风患者提供以目标为导向的功能改善.
没有足够的证据来推高剂量的BTX-A治疗性相关疼痛 (SRP).

关键词:

肉毒毒素A是一种肉毒毒素.功能性结果的结果.高剂量的高剂量疼痛疼痛疼痛疼痛性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性等.一次性中风中风中风中风中风

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