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铁氧化物 (CoFe₂O₄) 纳米粒子诱导子中的毒性

Muhammad Shahid Khan¹, Saeed Ahmad Buzdar¹, Riaz Hussain²

¹Institute of Physics, The Islamia University, Bahawalpur 63100, Pakistan.

Veterinary sciences

|August 25, 2023

概括

合成的铁氧化物纳米粒子 (CIONPs) 显示出作为MRI对比剂的潜力,但在子中诱导毒性. 研究显示血液参数,血清生物化学和多个器官的组织学损伤的显著变化,突出了安全问题.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
毒理学毒理学毒理学

背景情况:

纳米粒子具有独特的特性,如抗菌能力,推动市场增长.
纳米颗粒的毒理机制仍然不完全理解.
铁氧化物纳米粒子 (CIONPs) 是为潜在的应用而合成的,包括作为MRI对比剂.

研究的目的:

为了确定合成氧化铁纳米颗粒 (CIONPs) 在子中的毒性.
评估CIONP作为磁共振成像 (MRI) 的对比剂的潜力.

主要方法:

通过共同降水合成的CIONPs,以XRD,舍勒公式和TEM为特征.
用VSM测量的磁性;MRI放松度在0.35T时评估.
向子静脉注射CIONPs,随后在暴露后5天和10天进行血液学,血清生物化学和组织学分析.

主要成果:

CIONP表现出适用于MRI对比剂的磁性特性 (和磁化率为50.1emug-1,r2/r1比为6.63).
血液学分析显示治疗子的参数下降,白细胞增加和中性粒细胞增加.
血清生物化学发现了显著的变化,组织学检查显示肝脏,脏,脏,心脏和大脑受损.

结论:

氧化铁纳米粒子 (CIONPs) 显示出作为MRI对比剂的潜力.
然而,CIONPs在子中引起显著的毒性,由血液学,生化学和组织学变化证明.
需要进一步的研究来了解和减轻CIONPs在临床应用之前的毒性作用.

关键词:

XRD XRD 在线观看血液生物化学血液生物化学铁氧化物 (CoFe2O4) 纳米粒子 (CIONPs) 是一种组织病理学组织病理学磁共振成像技术的使用子子子子放松性放松性

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