慢性缺甲状腺症与皮层骨密度增加有关,使用高分辨率的外周定量计算断层扫描进行评估
Renata Gervais Santa Rosa1,2, Simone Polonine3, Alinie Pichone4
1Endocrinology Division, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. renatagsr@yahoo.com.br.
Endocrine
|August 25, 2023
概括
患有慢性术后偏偏甲状腺症 (hypoPT) 的女性表现出更高的骨矿物质密度 (BMD) 和皮质骨测量. 尽管骨折风险低,但一些患者有脊椎骨折,与骨周转的联系不清楚.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是一门学科.
背景情况:
- 慢性外科术后偏偏甲状腺症 (hypoPT) 可能会影响骨健康.
- 了解骨矿物质密度 (BMD),微型结构和 hypoPT 骨折风险至关重要.
研究的目的:
- 为了评估 BMD,骨微型结构,和骨折的患病率在女性慢性术后 hypoPT.
- 在hypoPT患者和健康对照者之间比较这些参数.
主要方法:
- 截面研究比较了27名患有hypoPT的女性和44名对照女性.
- 双能X射线吸收计 (DXA) 用于区域性BMD和脊椎骨折.
- 高分辨率的外围定量CT (HR-pQCT) 用于体积 BMD 和微架构.
- 生物化学标记 (FGF23,ICTP,P1NP) 和FRAX工具用于骨折风险评估.
主要成果:
- 没有普遍的临床骨折,FRAX估计的重大/部骨折风险较低.
- 两名hypoPT患者有中度至重度的形态测量脊椎骨折.
- 假PT妇女的区域性BMD (腰椎,部) 和皮质体积BMD (半径,部) 较高.
- 脊椎骨没有受到影响;P1NP和ICTP建议的低骨周转率.
结论:
- 在hypoPT女性中,脆弱性骨折的患病率较低,与低FRAX风险保持一致.
- 与对照组相比,HypoPT患者表现出增加的区域和皮质体积 BMD.
- 在hypoPT中,较高的骨密度和骨周转率下降之间的关联仍然不清楚.
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