运动可以防止葡萄糖皮质激素诱导的心肌4-氨酸的产生
Umit Hayta1, Senay Akin2, Irem Gungor1
1Division of Exercise and Sport Physiology, Faculty of Sport Sciences, Hacettepe University, Ankara, Turkey.
Cardiovascular drugs and therapy
|August 25, 2023
概括
在老鼠中,长期使用德克萨梅他治疗增加了心脏氧化应激标志物4-氨 (4-HNE). 运动训练有效地抵消这种影响,减轻心肌损伤.
科学领域:
- 心血管生理学心血管生理学
- 氧化压力研究研究 氧化压力研究
- 运动科学 运动科学
背景情况:
- 已知葡萄糖皮质类药物 (GCs) 会提高心肌氧化应激.
- 4-Hydroxynonenal (4-HNE) 蛋白质添加物是与心血管疾病相关的氧化损伤的指标.
- 运动训练通过减少氧化应激减轻心脏保护作用.
研究的目的:
- 调查长期使用德克萨米他对心肌4-HNE水平的影响.
- 确定同时进行运动训练对德克萨米他诱导的心肌4-HNE变化的影响.
- 为了评估运动对热冲击蛋白表达的影响,在德克萨米他治疗的背景下.
主要方法:
- 24只雌性Wistar白色老鼠被分为三个组:静止控制,静止德甲治疗和运动训练-德甲治疗.
- 德克萨米他每天服用1mg/kg,持续28天,对照组接受盐水.
- 运动训练需要每天60分钟,每周5天,每周28天以25米/分钟的速度进行.
- 心肌4-HNE,Hsp72和pHsp25/Hsp25比率的量化使用了西班牙的Blot.
主要成果:
- 与对照组相比,甲显著增加了心肌4-HNE水平 (p < 0.05).
- 运动训练防止了德克萨米他诱导的4-HNE增加 (p > 0.05与对照组相比).
- 运动训练显著增加了心肌的Hsp72表达 (p < 0.001) 和减弱了德甲诱导的Hsp25酸化 (p < 0.001).
结论:
- 长期使用德克萨米他会提高心脏4-HNE水平,这表明氧化应激增加.
- 运动训练有效地抵消了甲诱导的心肌4-HNE的增加.
- 运动训练调节热冲击蛋白反应,可能有助于其对抗葡萄糖皮质激素诱导的损伤的心脏保护作用.
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