在耐火性皮肤肌炎病例中突出的线粒体病理:巧合还是因果?
Antonio Lauletta1, Lanfranco De Carolis2, Valentina Teresi2
1Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Neuromuscular and Rare Disease Centre, Sant'Andrea Hospital, SAPIENZA University of Rome, Via Di Grottarossa 1035-1039, 00189, Rome, Italy. antonio.lauletta@uniroma1.it.
概括
抗Mi-2皮质肌炎 (DM) 中的线粒体异常可能表明严重的疾病和治疗反应不佳. 简氏激酶 (JAK) 抑制剂在线粒体功能障碍的耐火病例中表现有前途.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 线粒体变化在零星的包容体肌肉炎和带有线粒体病理的多重肌肉炎中很常见,通常与治疗结果不佳有关.
- 线粒体肌肉病理在皮肤肌炎 (DM) 中很少被报告,其与治疗反应的关联仍然不清楚.
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