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对低维生素B6饮食诱导妊娠糖尿病的敏感性是由小鼠的菌株差异调节的

Philip Spinelli¹, Ashley M Fields¹, Sierra Falcone¹

¹Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

|August 25, 2023

概括

在小鼠中,孕期糖尿病的风险因遗传背景而异. 与C57BL/6J小鼠不同,DBA/2J小鼠受到低维生素B6诱导的妊娠糖尿病的保护,这是由于其较高的组织非特异性性酸酶 (ALPL) 活性.

科学领域:

生殖生物学生殖生物学
营养科学营养科学
内分泌学在内分泌学.

背景情况:

孕期糖尿病 (GDM) 对母亲和婴儿的健康构成风险.
胰腺小岛中的血清激素信号传递对于怀孕期间的β细胞增殖至关重要.
维生素B6缺乏会破坏血清的合成,并且与C57BL/6J小鼠的GDM表型有关.

研究的目的:

调查小鼠对低维生素B6诱导的GDM差异敏感性的遗传基础.
测试假设,较高的组织非特异性酸酶 (ALPL) 活性可以保护DBA/2J小鼠免受GDM.

主要方法:

在怀孕的C57BL/6J和DBA/2J小鼠中对葡萄糖耐受性和胰岛素分泌的比较,这些小鼠接受了维生素B6缺乏的饮食.
在两种小鼠菌株中评估ALPL表达和酶活性.
给低维生素B6饮食中的DBA/2J小鼠服用ALPL抑制剂 (SBI-425).

主要成果:

怀孕的DBA/2J小鼠在低维生素B6饮食中,与C57BL/6J小鼠不同,没有发展过高血糖或葡萄糖不耐受.
与C57BL/6J小鼠相比,DBA/2J小鼠表现出更高的ALPL表达和活性.
在DBA/2J小鼠中抑制ALPL,在维生素B6缺乏的情况下,SBI-425诱导葡萄糖不耐受.

结论:

遗传因素,特别是更高的ALPL活性,在DBA/2J小鼠中提供了对维生素B6缺乏引起的GDM的保护.
在妊娠期间,ALPL在调节维生素B6的生物可用性和调节代谢反应方面发挥着至关重要的作用.
针对ALPL活动可能为管理GDM提供治疗策略.

关键词:

性酸酶是一种性性酸酶.孕期糖尿病孕期糖尿病血清胺 (serotonin) 是一种神经元.一个特定菌株的特定菌株.

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