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通过Cocrystal工程黄素加速伤口愈合,减少痕

Ali Samie^1,2, Hoda Alavian^1,2, Zeinab Vafaei-Pour^3,4

¹Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran.

Molecular pharmaceutics

|August 25, 2023

概括

这项研究表明,与单独使用黄素相比,黄素-黄素共晶 (CUR-PYR) 显著改善伤口愈合并减少痕. 在体内,CUR-PYR表现出优异的抗菌和细胞活力效应,导致伤口更快地关闭和痕形成最小.

科学领域:

制药科学和超分子化学.
伤口愈合和再生医学.
药物输送和材料科学.

背景情况:

制药共晶是人工设计的固体,可以增强药物的物理化学性质.
黄素 (CUR) 具有治疗潜力,但其溶解性和生物可用性不佳.
这项研究探讨了用于伤口愈合和痕减少的制药共晶.

研究的目的:

为了合成和表征一种库尔库明 - 铁醇共晶体 (CUR-PYR).
评估CUR-PYR在促进伤口愈合和减少痕方面的有效性.
为了研究CUR-PYR的体外和体内性能.

主要方法:

通过液体辅助研磨 (LAG) 合成的CUR-PYR,并使用FT-IR,DSC和PXRD进行了表征.
在体外抗菌检测对抗格拉姆阴性和格拉姆阳性细菌.
在人体皮肤纤维细胞 (HDF) 和NIH-3T3细胞的体外细胞活力研究.
在老鼠体内15天内进行伤口愈合研究,将CUR-PYR膏与对照剂进行比较.

主要成果:

与CUR相比,CUR-PYR表现出增强的抗菌活性和改善的HDF/NIH-3T3细胞活力.
用CUR-PYR膏治疗的伤口在第12天完全关闭,明显比对照组更快.
与其他组相比,CUR-PYR治疗导致痕最小 (3.89%).
组织病理学分析证实CUR-PYR的优异伤口愈合,再生和原沉积.

结论:

提高CUR-PYR的溶解度是加速伤口关闭和组织再生的关键.
制药性共晶,特别是CUR-PYR,为有效的伤口愈合和痕管理提供了一个有前途的治疗策略.
这项研究开创了制药共晶在伤口护理中的应用.

关键词:

库尔库明是一种黄素.组织病理学组织病理学在体外/体内生物评估.制药类的共晶体减少伤减少痕的方法伤口愈合伤口愈合

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