腹膜内膜异位症和深透性内膜异位症的临床病理相关性
Ming-Yao Qiu1, Ya-Ping Wang2, Ran Ren1
1Department of Obstetrics and Gynecology, Dalian Municipal Women and Children's Medical Center (Group), Dalian City, China.
Annals of medicine
|August 25, 2023
概括
腹膜内膜异位症 (PEM) 和深透性子宫内膜异位症 (DIE) 具有相似的骨盆位置和受体表达. 一些PEM病变可能会进展到DIE,这表明它们代表了同一疾病的不同阶段.
科学领域:
- 妇科 妇科 妇科 妇科
- 病理学 病理学 病理学
背景情况:
- 腹膜内膜异位症 (PEM) 和深层透性内膜异位症 (DIE) 是内膜异位症的不同的临床表现.
- 了解它们的差异和相似之处对于诊断和治疗至关重要.
研究的目的:
- 调查PEM和DIE的临床和病理学特征.
- 分析骨盆分布,组织病理学特征,免疫组织化学特征,以及PEM和DIE的腹入侵.
主要方法:
- 对100名PEM和DIE患者的回顾性分析.
- 收集和分析了131个PEM和37个DIE标本.
- 与22个eutopic子宫内膜控制样本进行比较.
- 组织病理学和免疫组织化学分析,包括ER,PR和Ki-67表达.
主要成果:
- PEM和DIE主要位于后骨盆腔.
- 在PEM形式中,在他的病理成分 (腺体,肌肉,肌肉,纤维组织,血管) 中存在显著差异.
- 在PEM和DIE中,雌激素受体 (ER) 和孕激素受体 (PR) 的高表达.
- 与其他PEM病变相比,DIE中的Ki-67表达显著更高,表明增殖活性更大.
- 白色病变显示出比透明和膀性病变更深的腹下侵袭.
结论:
- PEM和DIE可能代表同一疾病的不同发展阶段.
- 活跃的棕色PEM病变可以表现出入侵性质,并可能发展为DIE.
- 组织病理学差异和不同的侵袭深度突出了子宫内膜异位症进展的频谱.
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