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Updated: Jul 18, 2025

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

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上腺体空间密度在人类心房中的亲节律失常作用:一个in-silico研究

Karl Magtibay1, Stéphane Massé2, Kumaraswamy Nanthakumar2

  • 1Biomedical Signal and Image Processing Laboratory, Faculty of Engineering and Architectural Science, Toronto Metropolitan University, Toronto, Ontario, Canada.

PloS one
|August 25, 2023
PubMed
概括

慢性压力会导致自主功能障碍,导致心房内上腺体空间密度 (ASD) 增加. 较高的ASD水平促进了心房电生理学变化和波浪碎片化,这可能解释了年轻患者心律失常的开始.

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
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